Disease primers
Disease primers help readers move from a clinical question to the CardiacNexus phenotypes that may be relevant. They summarize why a disease area appears in feature badges and which measurements are most useful to inspect first.
- Modality
- All modalities
- Pipeline step
- Clinical interpretation
- Outputs
- Disease-to-phenotype reading map
- Maturity
- Clinician review draft
Interpretation boundary
These pages are not diagnostic or treatment guidelines. They explain literature-supported phenotype context and point readers back to measured CardiacNexus outputs.
Primer index
| Disease area | Primary phenotype families |
|---|---|
| Heart failure and cardiomyopathy | Volumes, EF, cardiac output, strain, atrial function |
| Hypertrophic cardiomyopathy and LV hypertrophy | LV mass, wall thickness, T1, strain, LVOT context |
| Ischemic heart disease and myocardial infarction | EF, regional thickening, strain, post-systolic features, T1 context |
| Atrial fibrillation and atrial remodeling | LA/RA size, emptying fractions, sphericity, atrial strain context |
| Valvular heart disease | Aortic root, LVOT, flow, regurgitant fraction, remodeling |
| Pulmonary hypertension and right-heart remodeling | RV/RA size, RV function, AVPD, flow context |
| Aortic disease and aortopathy | Aortic diameters, arch geometry, tortuosity, distensibility |
| Infiltrative and inflammatory cardiomyopathy | Native T1, corrected T1, mass, wall thickness, strain |
How to use these pages
Start with the disease primer when the clinical question is disease-first. Move to phenotype pages when the question is measurement-first, such as checking LV: EF [%], LA: V_max [mL], or native T1 outputs.
Source audit
- Primer routing checked against
website/src/components/Feature.tsxand the disease badges used in promoted phenotype pages. docs/data/reference_sources.ymlexists and remains the current source registry for disease-context and method references.- Disease primers are draft interpretation aids, not clinical guidelines, diagnostic criteria, management recommendations, or phenotype-to-ICD classifiers.
- Textbook context boundary: broad Braunwald/Hurst disease background was treated only as clinical context; the current primer index is supported by page-specific phenotype references and registry-backed disease-context citations.
- Textbook routes checked: Braunwald heart failure pages 29-142, atrial fibrillation pages 173-192, diseases of the aorta pages 261-289, valvular heart disease pages 58-129, hypertrophic cardiomyopathy pages 172-184, myocarditis pages 185-200, pulmonary hypertension pages 286-308, and coronary disease/MI pages 1-221 in the relevant Braunwald parts. These routes are not used as diagnostic guidance on this index.
References
- Kawel-Boehm N, Hetzel SJ, Ambale-Venkatesh B, Captur G, Francois CJ, Jerosch-Herold M, Salerno M, Teague SD, Valsangiacomo-Buechel E, Van Der Geest RJ, Bluemke DA. Reference Ranges ("Normal Values") for Cardiovascular Magnetic Resonance (CMR) in Adults and Children: 2020 Update. Journal of Cardiovascular Magnetic Resonance. 2020;22(1):87.
- Petersen SE, Aung N, Sanghvi MM, Zemrak F, Fung K, Paiva JM, Francis JM, Khanji MY, Lukaschuk E, Lee AM, Carapella V, Kim YJ, Leeson P, Piechnik SK, Neubauer S. Reference Ranges for Cardiac Structure and Function Using Cardiovascular Magnetic Resonance (CMR) in Caucasians from the UK Biobank Population Cohort. Journal of Cardiovascular Magnetic Resonance. 2017;19(1):18.
- Bai W, Suzuki H, Huang J, Francis C, Wang S, Tarroni G, Guitton F, Aung N, Fung K, Petersen SE, Piechnik SK, Neubauer S, Evangelou E, Dehghan A, O'Regan DP, Wilkins MR, Guo Y, Matthews PM, Rueckert D. A Population-Based Phenome-Wide Association Study of Cardiac and Aortic Structure and Function. Nature Medicine. 2020;26(10):1654-1662.